PUBLICATIONS
MyBibliography
ResearchGate
GoogleScholar
Covers
Lummertz da Rocha et al., Physical Chemistry Chemical Physics, 2013
Cahan et al., Cell, 2014
Selected Publications
Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP
Jing R, Falchetti M, Han T, Najia M, Hensch LT, Meader E, et al. Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP. Cell Stem Cell. 2025 Jan 2;32(1):71-85.e5. doi: 10.1016/j.stem.2024.12.008.
The dynamics of hematopoiesis over the human lifespan
Li H, Côté P, Kuoch M, Ezike J, Frenis K, Afanassiev A, et al. The dynamics of hematopoiesis over the human lifespan. Nat Methods. 2024 Dec;21(11):2212-2224. doi: 10.1038/s41592-024-02495-0.
Systemic cell–cell communication in cancer
Lummertz da Rocha E. Systemic cell-cell communication in cancer. Nat Rev Genet. 2024 Oct;25(10):730. doi: 10.1038/s41576-024-00785-z.
The epigenetic state of the cell of origin defines mechanisms of leukemogenesis
Li Z, Fierstein S, Tanaka-Yano M, Frenis K, Chen CC, Wang D, et al. The epigenetic state of the cell of origin defines mechanisms of leukemogenesis. Leukemia. 2024 Oct;38(1):87-97. doi: 10.1038/s41375-024-02428-y.
Single-cell resolution characterization of myeloid-derived cell states with implication in cancer outcome
Guimarães GR, Maklouf GR, Teixeira CE, De Oliveira Santos L, Tessarollo NG, De Toledo NE, et al. Single-cell resolution characterization of myeloid-derived cell states with implication in cancer outcome. Nat Commun. 2024 Jul 7;15(1):5694. doi: 10.1038/s41467-024-49916-4.
RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia
Marion W, Koppe T, Chen CC, Wang D, Frenis K, Fierstein S, et al. RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia. Leukemia. 2023 Jun;37(8):1698-1708. doi: 10.1038/s41375-023-01945-6.
Cross-activation of FGF, NODAL, and WNT pathways constrains BMP-signaling-mediated induction of the totipotent state in mouse embryonic stem cells
Meharwade T, Joumier L, Parisotto M, Huynh V, Lummertz da Rocha E, Girousi E, et al. Cross-activation of FGF, NODAL, and WNT pathways constrains BMP-signaling-mediated induction of the totipotent state in mouse embryonic stem cells. Cell Rep. 2023 May 30;42(5):112438. doi: 10.1016/j.celrep.2023.112438.
EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity
Fasolino F, Hsieh CSG, Cason SEK, Li Y, Nabel CS, He MJ, et al. EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity. Cell Stem Cell. 2022 Aug 4;29(8):1181-1196.e6. doi: 10.1016/j.stem.2022.06.014.
Lifelong multilineage contribution by embryonic-born blood progenitors
Patel SH, Christodoulou C, Weinreb C, Yu Q, da Rocha EL, Pepe-Mooney BJ, et al. Lifelong multilineage contribution by embryonic-born blood progenitors. Nature. 2022 Jun;606(7915):747-753. doi: 10.1038/s41586-022-04804-z.
Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells
Morris V, Wang D, Li Z, Marion W, Hughes T, Sousa P, et al. Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells. Cell Rep. 2022 Apr 26;39(4):110752. doi: 10.1016/j.celrep.2022.110752.
CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development
Lummertz da Rocha E, Kubaczka C, Sugden WW, Najia MA, Jing R, Markel A, et al. CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development. Nat Cell Biol. 2022 Apr;24(4):579-589. doi: 10.1038/s41556-022-00884-1.
Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis
Wang D, Tanaka-Yano M, Meader E, Kinney MA, Morris V, Lummertz da Rocha E, et al. Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis. Cell Rep. 2022 Apr 5;39(1):110587. doi: 10.1016/j.celrep.2022.110587.
Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2
Li X, Wang X, Ge H, Xie Q, Liu Y, Hao Q, et al. Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2. Stem Cell Reports. 2021 Jul 13;16(7):1718-1734. doi: 10.1016/j.stemcr.2021.05.014.
Introductions to the Community: Early-Career Researchers in the Time of COVID-19
Takayama K, Weaver LN, Lummertz da Rocha E, Lo Sardo V, Gehart H, Vu LP. Introductions to the community: early-career researchers in the time of COVID-19. Cell Stem Cell. 2020 Dec 3;27(6):853-855. doi: 10.1016/j.stem.2020.11.011.
Transcriptome Dynamics of Hematopoietic Stem Cell Formation Revealed Using a Combinatorial Runx1 and Ly6a Reporter System
Chen MJ, Lummertz da Rocha E, Cahan P, Kubaczka C, Hunter P, Sousa P, et al. Transcriptome dynamics of hematopoietic stem cell formation revealed using a combinatorial Runx1 and Ly6a reporter system. Stem Cell Reports. 2020 May 12;14(5):956-71. doi: 10.1016/j.stemcr.2020.03.020.
An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans
Delgobo M, Mendes DAGB, Kozlova E, Rocha EL, Rodrigues-Luiz GF, Mascarin L, et al. An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans. Elife. 2019 Oct 29;8:e47013. doi: 10.7554/eLife.47013.
The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia
Rowe RG, Lummertz da Rocha E, Sousa P, Missios P, Morse M, Marion W, et al. The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia. J Exp Med. 2019 Feb 6;216(3):527-38. doi: 10.1084/jem.20181765.
LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis
Zhu S, Zhang X, Weichert-Leahey N, Dong Z, Zhang C, Lopez G, et al. LMO1 synergizes with MYCN to promote neuroblastoma initiation and metastasis. Cancer Cell. 2017 Sep 11;32(3):310-323.e5. doi: 10.1016/j.ccell.2017.08.002.
Reconstruction of complex single-cell trajectories using CellRouter
Lummertz da Rocha E, Rowe RG, Lundin V, Malleshaiah M, Jha DK, Rambo CR, et al. Reconstruction of complex single-cell trajectories using CellRouter. Nat Commun. 2018 Mar 1;9(1):892. doi: 10.1038/s41467-018-03214-y.
Haematopoietic stem and progenitor cells from human pluripotent stem cells
Sugimura R, Jha DK, Han A, Soria-Valles C, Lummertz da Rocha E, Lu YF, et al. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 2017 May 17;545(7655):432-8. doi: 10.1038/nature22370.
NetDecoder: a network biology platform that decodes context-specific biological networks and gene activities
Lummertz da Rocha E, Ung CY, McGehee CD, Correia C, Li H. NetDecoder: a network biology platform that decodes context-specific biological networks and gene activities. Nucleic Acids Res. 2016 Jun 2;44(10):e100. doi: 10.1093/nar/gkw166.
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity
Wang W, Wang L, Lu J, Siedlak SL, Fujioka H, Liang J, et al. The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity. Nat Med. 2016 Jun;22(8):869-78. doi: 10.1038/nm.4130.
CellNet: Network Biology Applied to Stem Cell Engineering
Cahan P, Li H, Morris SA, Lummertz da Rocha E, Daley GQ, Collins JJ. CellNet: network biology applied to stem cell engineering. Cell. 2014 Aug 14;158(4):903-15. doi: 10.1016/j.cell.2014.07.020.